The enzymatic reduction of hydroxyguanidine.

نویسندگان

  • J B WALKER
  • M S WALKER
چکیده

This laboratory first became interested in hydroxyguanidine as a result of our studies on the mechanism of action of transamidination enzymes. We have found that transamidinases from Streptomyces griseus (2), mammalian pancreas (3) and kidney (4), and chicken and frog liver (5) can catalyze a transfer of the terminal formamidine group of arginine to hydroxylamine, with the formation of hydroxyguanidine.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The enzymatic cleavage of canavanine to homoserine and hydroxyguanidine.

Previous studies have shown canavanine to be a potent antagonist of arginine in Neurospora (1) and in some bacteria, but not in others (2, 3). Streptococcus faecaks belongs to the resistant group of bacteria and has been shown to degrade canavanine in two distinct ways: by reductive cleavage to guanidine and homoserine (4) and, to a lesser extent, by hydrolytic cleavage to ammonia and 0-ureidoh...

متن کامل

A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation.

This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of γ-glutamyl transpeptidase (γ-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).

متن کامل

The Study of Antimicrobial and Anti-Enzymatic Activity (Potato Poly Phenol Oxidase) of Cinnamomum Verum Hydrosol: A Laboratory Study

Background and Objectives: Cinnamon contains phenolic and non-phenolic bioactive compounds. The aim of this research was investigating the antimicrobial and anti-enzymatic properties of cinnamon (Cinnamomum verum) hydrosol. Materials and Methods: In this laboratory study, chemical composition of cinnamon hydrosol was analyzed by Gas chromatography–mass spectrometry method.  Antibacterial effec...

متن کامل

Investigations of Canavanine Biochemistry in the Jack Bean Plant, Canavalia ensiformia (L.) DC: I. Canavanine Utilization in the Developing Plant.

An ontogenetic study of the canavanine and soluble protein pools in the developing jack bean plant, Canavalia ensiformis (L.) DC., was conducted. Evidence was presented which clearly established the conversion of canavanine to canaline and urea as the principal pathway of canavanine utilization. The catabolic reactions of certain bacteria involving the formation of guanidine or hydroxyguanidine...

متن کامل

A self-consistent field molecular orbital study of hydroxyguanidine.

Theoretical self-consistent field molecular orbital calculations indicate that the hydroxyguanidinium ion can dissociate in alkaline or neutral medium by the loss of the hydroxyl proton, leading to the formation of a strong nucleophilic agent which can attack a positive receptor in enzymes, acting in this way as an antitumor and an antiviral agent. Geometry optimization, total energies, and net...

متن کامل

ذخیره در منابع من

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • The Journal of biological chemistry

دوره 234 6  شماره 

صفحات  -

تاریخ انتشار 1959